Paolo Antonacci opened his gallery in via del Babuino 141/A, Rome in 1998. Coming from a long line of Roman antique dealers, he had worked for over twenty years in the prestigious Rome and London galleries belonging to his father Giuseppe, a very well-known international antiquarian.

The gallery has also opened its spaces to exhibitions by contemporary artists and, over the years, it has developed a particular interest in little-known sector of antique photographs of the nineteenth century. The gallery participates in such major antiques fairs as the Biennale of Palazzo Corsini in Florence, the Biennale d'Arte at Palazzo Venezia in Rome and the Milano International Antique Show at Palazzo della Permanente in Milan. The gallery is a regular presence at prestigious international fairs like the Lifaf and Masterpiece in London and the Highlights in Munich.

In 2013 the Paolo Antonacci has participated at the Master Drawings Week in New York, as well as the Masterpiece, the Biennale and the Highlights. In the late Spring the gallery held a major exhibition focused on the collection of Danish and Roman nineteenth century paintings from the collection of Mr Jørgen Birkedal Hartmann.

Over the years, Paolo Antonacci has forged strong relationships with many national and international collectors, scholars and museum curators. He has sold important pictures to the major Roman museums like the Museo di Roma, the Galleria Nazionale d'Arte Moderna, the Musei Vaticani, the Museo del Corso, the American Academy of Rome, and to the Sovrintendenza per il Polo Museale Fiorentino in Florence and to many others significant institutions and private collections.